Contribution of α1 subunit-containing γ-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys
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منابع مشابه
Rat and Human Hippocampal a5 Subunit-Containing g- Aminobutyric AcidA Receptors Have a5b3g2 Pharmacological Characteristics
The g-aminobutyric acid (GABA)A receptor is a hetero-oligomer consisting of five subunits, the combination of which confers unique pharmacological properties to the receptor. To understand the physiological role of native GABAA receptors, it is critical to determine their subunit compositions. The pharmacological characteristics of human a5b3g2 and a5b3g3 GABAA receptors stably expressed in L(t...
متن کاملStoichiometry of δ subunit containing GABAA receptors
BACKGROUND AND PURPOSE Although the stoichiometry of the major synaptic αβγ subunit-containing GABAA receptors has consensus support for 2α:2β:1γ, a clear view of the stoichiometry of extrasynaptic receptors containing δ subunits has remained elusive. Here we examine the subunit stoichiometry of recombinant α4β3δ receptors using a reporter mutation and a functional electrophysiological approach...
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From Department of Biochemistry and Molecular Biology, Center for Brain Research 1 , Medical University of Vienna, Vienna, Austria 1 . Ecolé Normale Supérieure, Institut de Biologie de l’Ecole Normale Supérieure (IBENS) Paris France; Inserm U1024, Paris France; CNRS UMR8197, 75005 Paris, France 2 . Running Title: GABAA and P2X2 receptor interaction Address correspondence to: Isabella Sarto-Jack...
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Uterine contractions at parturition depend upon a variety of factors, including gamma-aminobutyric acid (GABA)-ergic stimulation. A new subunit of the GABA(A) receptor, pi, has recently been identified as being particularly abundant in the rat uterus. Reduced derivatives of progesterone, such as the 3alpha,5alpha-reduced derivative termed allopregnanolone, modulate GABA(A) receptor activity and...
متن کاملEnhanced Neurosteroid Potentiation of Ternary GABAA Receptors Containing the Subunit
Attenuated behavioral sensitivity to neurosteroids has been reported for mice deficient in the GABAA receptor subunit. We therefore investigated potential subunit-specific neurosteroid pharmacology of the following GABAA receptor isoforms in a transient expression system: 1 3 2L, 1 3 , 6 3 2L, and 6 3 . Potentiation of submaximal GABAA receptor currents by the neurosteroid tetrahydrodeoxycortic...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2008
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-008-1401-7